Solidago

 Asteraceae

The World Botanical Associates Web Page
Prepared by Richard W. Spjut
December 2004; August 2006

Solidago simplex
Near Fairbanks, AK
August 2003

Solidago salebrosa
Along South Fork of the Salmon River, Klamath NF, CA; August 2006

 

Solidago spathulata
Samoa Peninsular, Humboldt Co., CA
August 2006
 

USDA plant procurement record for cancer research

Solidago canadensis ssp. elongata

Solidago graminifolia

 

Chaturvedula V. S., B. N.  Zhou, Z. Gao Z, S. J. Thomas, S. M. Hecht and D. G. Kingston.  2004. New lupane triterpenoids from Solidago canadensis that inhibit the lyase activity of DNA polymerase beta. Bioorg Med Chem. 12: 62716275. Bioassay-directed fractionation of a methyl ethyl ketone extract of Solidago canadensis L. (Asteraceae), using an assay to detect the lyase activity of DNA polymerase beta, resulted in the isolation of the four new lupane triterpenoids 1-4 and the seven known compounds lupeol, lupeyl acetate, ursolic acid, cycloartenol, cycloartenyl palmitate, alpha-amyrin acetate, and stigmasterol. The structures of the new compounds were established as 3beta-(3R-acetoxyhexadecanoyloxy)-lup-20(29)-ene (1), 3beta-(3-ketohexadecanoyloxy)-lup-20(29)-ene (2), 3beta-(3R-acetoxyhexadecanoyloxy)-29-nor-lupan-20-one (3), and 3beta-(3-hetohexadecanoyloxy)-29-nor-lupan-20-one (4), respectively, on the basis of extensive 1D and 2D NMR spectroscopic interpretation and chemical modification studies. All 11 compounds were inhibitory to the lyase activity of DNA polymerase beta.