Lomatium caruifolium
Mariposa Co., CA
Spjut 14755, May 2002
Note: Preliminary Identification by R. Spjut was L. marginatum.  This was
reidentified by Roger Sanders to L. caruifolium
 

Lomatium californicum
 Kern Co., Caliente Ranch, CA. CNPS Chapter/Nature Conservancy  Field Trip,
24 May 2013 

Lomatium dasycarpum
San Diego Co., CA
Spjut & Marin 14673, April 2002

Lomatium dasycarpum
Kern Co., CA.
Piute Mt. 30 Apr 2005

Lomatium latilobum
Arches National Park, Utah
May 2008

Lomatium parryi
Clark Co., NV, Spjut 15292.
May 2003

Lomatium scabrum
Utah—Great Basin Desert-Plateaus. Dixie NF: Garfield Co.: Summit on east side of Hwy 12, ~15 mi south of Torrey; 38º02'06.4", 111º19.42.1", 2936 m.  Alpine meadows near quaking aspen forest.  Perennial from a tuberous root, flowers yellow, fruits immature.  Common in heavily grazed meadow, Richard Spjut & Paul Burchstead 16371, 24 June 2008.

Lomatium triternatum
Lassen Co., CA,
Spjut & Casterline 14791.
June 2002

Lomatium utriculatum
Carrizo Plain—Elkorn Plain, Kern Co., CA,
5 March 2010 

Lomatium utriculatum
Los Angeles NF, CA,
Spjut 15183; April 2003 

Chou S. C., M. C. Everngam, G. Sturtz and J. J. Beck.  2006. Antibacterial activity of components from Lomatium californicum.  Phytother.  Res. 20(2):153–156. “The isolation, characterization and bioactivity testing of compounds from Lomatium californicum (Nutt.) are described. Ethyl acetate and hexane extracts of the roots of L. californicum were subjected to vacuum liquid chromatography (VLC), flash column chromatography (FCC) and separation by normal- and reverse-phase high-performance liquid chromatography (HPLC). Six compounds were isolated successfully and characterized by 1D and 2D nuclear magnetic resonance (NMR) experimentation. The bioactivity of the known compounds (+)-falcarindiol, coniferyl ferulate, ferulic acid and (Z)-ligustilide were confirmed against the Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus. The known compounds senkyunolide I and trans-neocnidilide were also isolated but in too small a quantity for similar testing. Copyright 2006 John Wiley & Sons, Ltd.”

Lee T. T., Y. Kashiwada, L. Huang, J. Snider, M. Cosentino and K. H. Lee. 1994. Suksdorfin: an anti-HIV principle from Lomatium suksdorfii, its structure-activity correlation with related coumarins, and synergistic effects with anti-AIDS nucleosides. Bioorg. Med. Chem. 2(10): 1051–1056. “Suksdorfin (1), which is isolated from the fruit of Lomatium suksdorfii, was found to be able to inhibit HIV-1 replication in the T cell line, H9, with an average EC50 value of 2.6 +/- 2.1 microM. In addition, suksdorfin was also suppressive during acute HIV-1 infections of peripheral blood mononuclear cells, monocyte/macrophages and the promonocytic cell line, U937. Combinations of 1 and the anti-HIV nucleosides ddI and ddC demonstrated statistical synergy in inhibiting HIV-1 replication (ddC > ddI). However, the viral inhibition mediated by combining 1 with AZT was not statistically synergistic. Furthermore, the presence of suksdorfin did not antagonize the suppression mediated by the three nucleoside reverse transcriptase inhibitors. Comparison of the structure and activity of 1 with those of ten related compounds indicated that the dihydroseselin type of pyranocoumarin possessing a 4'-isovaleryl group is important to suksdorfin's enhanced anti-HIV activity.”

Meepagala K. M., G. Sturtz, D. E. Wedge, K. K. Schrader and S. O. Duke. 2005. Phytotoxic and antifungal compounds from two Apiaceae species, Lomatium californicum and Ligusticum hultenii, rich sources of Z-ligustilide and apiol, respectively. J. Chem. Ecol.31(7):1567–1578.  “The seeds of two Apiaceae species, Ligusticum hultenii and Lomatium californicum, were investigated. Preliminary bioassays indicated that methylene chloride extracts of seeds of both species contained selective phytotoxic activity against monocots and antifungal activity against Colletotrichum fragariae. Active constituents were isolated by bioassay-guided fractionation, and the structures were elucidated by NMR and GC-MS as apiol and Z-ligustilide, isolated from L. hultenii and L. californicum, respectively. Apiol and Z-ligustilide had I50 values of about 80 and 600 microM, respectively, for inhibition of the growth of Lemna paucicostata. The methylene chloride (CH2Cl2) extracts of the seeds and the isolated and purified compounds were tested against the 2-methylisobomeol-producing cyanobacterium (blue-green alga) Oscillatoria perornata, and the green alga Selenastrum capricornutum. The CH2Cl2 extracts of both Apiaceae species and apiol were weakly toxic to both species of phytoplankton, while Z-ligustilide was toxic to both with a lowest complete inhibitory concentration (LCIC) of 53 microM. Seeds of L. californicum and L. hultenii were found to be rich sources of Z-ligustilide (97 mg/g of dry seed) and apiol (40 mg/g of dry seed), respectively.”