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Gymnosperma glutinosum |
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Gomez-Flores,
R. L. Verstegui-Rodrguez, R. Quintanilla-Licea, P. Tamez-Guerra, E.
Monreal-Cuevas, R. Tamez-Guerra, and C. Rodrguez-Padilla. 2009. Antitumor
properties of Gymnosperma glutinosum leaf extracts.
Cancer Investigation 27( 2): 149–155. “The present
study was undertaken to validate the antitumor potential of Gymnosperma
glutinosum from regional people's account, using the in vitro and in
vivo L5178Y-R lymphoma murine model. Non-polar G. glutinosum crude
extracts were tested on L5178Y-R cells. We found significant (p < 0.05)
cytotoxic activity (up to 40%) of the hexane extract, which was further
fractioned; fraction 1 (F1) was then observed to produce up to 51%
apoptosis-mediated L5178Y-R cytotoxicity in vitro at concentrations lower
than 0.98 μ g/ml, and possess significant in vivo antitumor activity. This
study may support further evaluation of active F1 in clinical trials.” |
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