©The World Botanical Associates Web Page
Prepared by Richard W. Spjut
January 2006

Crescentia alata
Jalisco, Mexico
Spjut & Edson 6130
March 1980


Hetzel C. E, A. A. Gunatilaka, T. E. Glass,  D. G. Kingston, G. Hoffmann and R. K. Johnson.  Bioactive furanonaphthoquinones from Crescentia cujete. 1993. J. Nat. Prod. 56: 1500–1505.  “Bioassay-directed fractionation of the MeCOEt extract of Crescentia cujete (Bignonaceae) resulted in the isolation of (2S,3S)-3-hydroxy-5,6-dimethoxydehydroiso-alpha-lapachone [1], (2R)-5,6-dimethoxydehydroiso-alpha-lapachone [2], (2R)-5-methoxydehydroiso-alpha-lapachone [3], 2-(1-hydroxyethyl)naphtho[2,3-b]furan-4,9-dione [4], 5-hydroxy-2-(1-hydroxyethyl)naphtho[2,3-b]furan-4,9-dione [5], 2-isopropenylnaphtho[2,3-b]furan-4,9-dione [6], and 5-hydroxydehydroiso-alpha-lapachone [7]. Compounds 1-3 are new, and all compounds are bioactive, showing selective activity towards DNA-repair-deficient yeast mutants. The isolation, structure elucidation, and biological activities of these compounds are reported.”