Plants Collected by A

Plants Collected by A. S. Barclay in 1962
That Showed Antitumor Activity

©The World Botanical Associates Web Page
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 December 2006

 A. S. Barclay in Saltillo, Mexico, August 1974 assisting Ed Sallee in the large-scale collection of Bouvardia ternifolia for the isolation of bouvardin needed for clinical studies.

  Mae Hatcher, Administrative Assistant and Robert Perdue, Jr., Chief of the Medicinal Plant Resources Laboratory, Beltsville, MD (1960–1978).  Photo taken sometime during the mid 1970's

Plants Collected by Arthur S. Barclay During 1962
From the Western United States

Genus Species Family Plant parts State Coll. # Tumor Other tumors
Abies magnifica Pinaceae tw-lf OR B-1370 SA  
Aesculus californica Hippocastanaceae fl CA B-1195 SA  
Apocynum pumilum Apocynaceae rt-st-lf-fl CA B-1250 SA  
Arnica chamissonis Asteraceae rt-st-lf-fl CA B-1489 KB  
Arnica longifolia Asteraceae rt-st-lf-fl OR B-1434 KB  
Aruncus vulgaris Rosaceae rt OR B-1450 SA  
Asclepias eriocarpa Asclepiadaceae rt-st-lf-fl CA B-1362 KB PS
Calystegia soldanella Convolvulaceae rt-st-lf-fl CA B-1243 WA  
Chlorogalum pomeridianum Liliaceae bu CA B-1197 WA PS
Cornus nuttallii Cornaceae tw-lf CA B-1192 SA  
Datisca glomerata Datiscaceae rt CA B-1354 KB  
Epilobium angustifolium Onagraceae rt-st-lf-fl CA B-1262 LL  
Eriogonum nudum Polygonaceae rt-st-lf-fl NV B-1517 WA  
Eriogonum umbellatum Polygonaceae rt-st-lf-fl CA B-1327 WA  
Eriophyllum lanatum Asteraceae rt-st-lf-fl CA B-1408 LL PS
Fraxinus latifolia Oleaceae sb CA B-1215 LL  
Grayia spinosa Chenopodiaceae tw-lf-fr CA B-1562 LL  
Heliotropium curassavicum Boraginaceae rt-st-lf-fl CA B-1618 DA WA
Horkelia fusca Rosaceae rt-st-lf-fl CA B-1307 WA PS
Juniperus occidentalis Cupressaceae sb CA B-1556 KB  
Lotus crassifolius Fabaceae rt OR B-1437 WA PS
Marah oreganus Cucurbitaceae rt, fr CA B-1242 KB  
Mimulus primuloides Scrophulariaceae rt-st-lf-fl CA B-1380 WA  
Myrica californica Myricaceae st-lf-fr CA B-1209 KB  
Oenothera hookeri Onagraceae rt CA B-1365 SA  
Paxistima myrsinites Celastraceae rt OR B-1453 LL PS
Penstemon deustus Scrophulariaceae rt-st-lf-fl CA B-1319 WA PS
Pinus contorta Pinaceae tw-lf OR B-1480 LL  
Pinus lambertiana Pinaceae tw-lf CA B-1504 WA  
Plantago maritima Plantaginaceae rt-st-lf-fl CA B-1231 LL  
Polygonum coccineum Polygonaceae rt-rh-st-lf CA B-1403 WA  
Polygonum newberryi Polygonaceae st-lf-fl CA B-1315 WA  
Polygonum paronchynia Polygonaceae rt-st-lf-fl CA B-1246 SA  
Purshia tridentata Rosaceae rt CA B-1313 KB  
Quercus chrysolepsis Fagaceae fr CA B-1512 WA  
Quercus kelloggii Fagaceae st-lf CA B-1357 WA  
Ribes erythrocarpum Grossulariaceae rt-st-lf-fl OR B-1421 SA  
Rosa californica Rosaceae tw-lf-fl-fr CA B-1343 WA  
Rubus parviflorus Rosaceae st-lf-fr CA B-1255 WA  
Rubus procerus Rosaceae st-lf CA B-1193 WA  
Salix exigua Salicaceae tw-lf CA B-1361 WA  
Sambucus caerulea Caprifoliaceae tw-lf CA B-1194 LL  
Senecio triangularis Asteraceae rt-st-lf-fl CO B-1148 SA  
Sidalcea oregana Malvaceae rt-st-lf-fl CA B-1398 WA  
Spiraea densiflora Rosaceae rt CA B-1335 WA  
Stephanomeria pauciflora Asteraceae rt-st-lf-fl CA B-1607 KB  
Taxus brevifolia Taxaceae sb WA B-1645 KB LE, PS, WA
Tsuga heterophylla Pinaceae tw-lf-fr CA B-1299 WA  
Umbellularia californica Lauraceae sb CA B-1204 SA LL
Vaccinium nivictum Ericaceae rt-st-lf-fl CA B-1369 WA  
Vaccinium scoparium Ericaceae st-lf-fl-fr OR B-1423 SA LL
Veratrum californicum Melanthiaceae st-lf CA B-1376 WA PS
Vicia angustifolia Fabaceae rt-st-lf-fl CA B-1253 WA  
Vitis girdiana Vitaceae fr CA B-1550 SA  
Wyethia angustifolia Asteraceae st-lf CA B-1379 SA  
Yucca brevifolia Agavaceae lf CA B-1614 SA  

Dr. Barclay collected mostly in California, western Nevada, Oregon and Washington, 494 collection numbers were accounted for, and undetermined number had been made in other states as one active plant was from Colorado.  Seventeen of 36 plants that had separate plant parts active were represented by activity in root (rt), stem-bark (sb), flower (fl) or fruit (fr). In 1965, Barclay collected additional general samples from southern Californica that led to the discovery of active species Eriophyllum confertiflorum, Holacantha emoryi, Tetracoccus dioicus and Thalictrum fendleri.  It is interesting to note that holacanthone (from Holacantha) was another compound, in addition to taxol from Taxus brevifolia, and camptothecin from Camptotheca acuminata—that was isolated by Monroe Wall's group—had undergone clinical trials.  Other clinically important antitumor compounds related to species that Barclay collected include thalicarpine from Thalictrum dasycarpum, and indicine-n-oxide from Heliotropium indicum.   While most of the active agents in the above list of plants were undoubtedly tannins and saponins, one might still find other active compounds in the above plants that could lead to new anticancer drugs (e.g., alkaloids in Veratrum californicum). Additionally, it might be noted that C-j Chang at Purdue University had found antitumor activity in samples collected by Spjut during the late 1980's in Purshia tridentata root and Spiraea densiflora root.  The Purshia sample was collected from the same general area where Barclay collected his KB active sample, whereas a recollection from another state obtained by Spjut was reported by Chang to have failed reconfirmation.  As noted on the web page for Purshia, there is a great deal of variation in the genus that needs taxonomic study.